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Considerations on the Development of a Zika Virus Vaccine

Hilary D. Marston, M.D., M.P.H.; Nicole Lurie, M.D., M.S.P.H; Luciana L. Borio, M.D., and Anthony S. Fauci, M.D. recently published an article in the New England Journal of Medicine exploring the considerations associated with the development of a Zika virus vaccine. The article urges investigators to gather high-quality data on safety, immunogenicity and efficacy, and to pursue randomized controlled trials to achieve this. The authors outline three potential strategies for conducting clinical trials, and suggest support for trials evaluating multiple vaccine candidates over time with a common control group. The article states: “Carefully executed evaluation of candidate Zika vaccines, coupled with thoughtful planning for eventual use and deployment, will be essential to durable control of Zika virus infections.” Following is a link to the entire piece:

New England Journal of Medicine:

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